Most studies of neural encoding still rely on patch-clamp noise injection, an invasive method that poorly replicates the conductance-based, dendritic inputs neurons receive in vivo. Optogenetics offers a non-invasive alternative, but turning noisy light into realistic synaptic conductances requires new strategies.
We present a framework that uses Gaussian-noise illumination of...
Gastroparesis is characterized by severely delayed gastric emptying without physical obstruction, causing symptoms such as nausea, vomiting, and epigastric pain. Currently, no treatment reliably restores gastric emptying. Optogenetics involves genetically introducing light-sensitive proteins into target cells, enabling precise stimulation with high spatial and temporal resolution. We...
Adaptive mechanisms are essential for maintaining a balanced operating regime of neuronal networks. Disturbances in these mechanisms—for example, mutations in ion channels, synaptic receptors, or scaffold proteins—can lead to epilepsy, neurodevelopmental or neurodegenerative disorders. Recent advances in single-cell transcriptomics, together with patient-derived organoid technology, provide...
