Speaker
Agostina Palmigiano
(University College London)
Description
The cerebral cortex exhibits strong recurrent connectivity governed by complex wiring rules. Recent advances allow probing this circuitry through optogenetic perturbations of single or few neurons, yet a general theory linking these responses to underlying connectivity is lacking. Here, we develop an exactly solvable framework to predict responses to perturbations in networks with multiple cell types and space- and feature-dependent connectivity. Analysis of these equations reveals simple rules that govern perturbation response patterns. Comparison with experimental data imposes new constraints on the connectivity parameters and enables predictions of the responses of unmeasured cell types and novel experimental conditions.
