GPF Symposium 2023

Session

Session 2 : Crosslinking

Jun 29, 2023, 12:40 PM

MPI-NAT City Campus

4. Henning Urlaub – MPI für Multidisziplinäre Naturwissenschaften, Göttingen

6/29/23, 12:40 PM

RNA/DNA-protein crosslinking mass spectrometry - Applications of UV and chemical crosslinking

Crosslinking mass spectrometry (XL-MS) can resolve sites of interaction in protein-RNA and DNA complexes at single amino acid and nucleic acid resolution. Processing of (large) XL-MS data, reliable assignment, and visualization of crosslinking results – including annotation of spectra –remain key...

5. Andrew Norris – Thermo Fisher Scientific

6/29/23, 1:20 PM

Bound Together: The picture-perfect marriage of crosslinking mass spectrometry and Cryo-EM

Yuqi Shi(1); Ye Hi(1); Leigh Foster(2), Albert Konijnenberg(3), Ryan Bomgarden(2), Rosa Viner(1)

Thermo Fisher Scientific, (1) San Jose, CA, (2) Rockford, IL, (3) Eindhoven, NL

Cross-linking mass spectrometry (XL-MS) has become a powerful structural tool for mapping protein-protein interactions...

6. Juri Rappsilber – Technische Universität Berlin

6/29/23, 1:40 PM

Protein structures inside cells – how and why

Accurately modelling the structures of proteins and their complexes using artificial intelligence is revolutionizing molecular biology. Remaining challenges result from the limited information available on specific protein states including protein-protein interactions. We present how experimental data enable systematically modelling novel...