Conference: Protein Folding on the Ribosome

Dec 15, 2024, 3:00 PM → Dec 18, 2024, 2:00 PM Europe/Berlin

Harnack House

Prof. Marina Rodnina

Following the exciting meetings in Cambridge, Stockholm, Berlin, and Baltimore, we will continue the discussion of the emerging concept of the translational tuning of protein folding. The focus of this meeting will be on nascent polypeptide chain structure and folding, regulation of translation, and nascent chain targeting and translocation to membranes.

 

 

Organizers:

Prof. Marina Rodnina Max Planck Institute for Multidisciplinary Sciences, Germany	Prof. John Christodoulou University College of London, UK	Prof. Gunnar von Heijne Stockholm University, Sweden
Prof. Zoya Ignatova University of Hamburg, Germany	Prof. Anton Komar Cleveland State University, USA	Prof. Susan Marqusee University of California, Berkley, USA

 

 

Support from:

• Dr. John Vitullo, CEO, Omega Laboratories, Inc

 

• Boehringer Ingelheim Stiftung

  

Abstract Book.pdf

Protein Folding on the Ribosome_V5_web_.pdf

Sun, December 15

Registration

Opening

Marina Rodnina

Session 1: FOLDING and ASSEMBLY

Chair: Marina Rodnina

Keynote: Molecular chaperone functions in protein folding in situ

Ulrich Hartl

Talk: Co-translational assembly of the multi-tRNA synthetase complex

Paul Fox

Dinner

Reception

Informal discussions at Harnack House

Mon, December 16

Focus Talk: The ribosome lowers the entropic penalty of protein folding

John Christodoulou

SESSION 2: INSIDE THE TUNNEL

Chair: Gunnar von Heijne

Talk: Flip-flop binding in the exit tunnel of the ribosome-targeting antimicrobial peptides

Alexander Mankin

Short Talk: Cotranslational Protein Folding Through Non-native Structural Intermediates 1

Amir Bitran

Short Talk: Cotranslational Protein Folding Through Non-native Structural Intermediates 2

Siyu Wang

Break

Talk: Deciphering the dynamics of divergent co-translational assembly pathways

Ayala Shiber

Talk: A translation ruler to probe early cotranslational folding

Marina Rodnina

Talk: The importance of the N-terminus is nascent chain folding

Susan Marqusee

Lunch

SESSION 3: DOMAIN FOLDING

Chair: Zoya Ignatova

Talk: Cotranslational folding of disulfide rich proteins – an RBD domain story

Eugene Shakhnovich

Talk: Early domain folding and interactions in ABC transporter CFTR

Ineke Braakman

Talk: Mapping Protein-Protein Interactions at Birth

Silvia Cavagnero

Break

Short Talk: Coordination of molecular chaperones during cotranslational folding of a multidomain protein

Alzbeta Roeselova

Short Talk: Following the co-translational folding of a multidomain protein

Ane Metola

Talk: When protein folding and assembly fails: membrane protein quality control at the ER

Rebecca Voorhees

Short Talk: Cotranslational protein misfolding and mis-assembly on translating ribosomes

Lisa Cabrita

Talk: Nascent Chain-Mediated Ribosomal Frameshifting During Membrane Protein Translation

Jonathan Schlebach

Dinner

Poster Session 1

Tue, December 17

SESSION 4: EMERGING METHODS

Chair: Susan Marqusee

Talk: Visualisation of protein biogenesis in mammalian cells

Juliette Fedry

Talk: Protein Folding: Queerer than we suppose, or queerer than we can suppose

Stephen Fried

Talk: Stabilities of ribosome-bound and soluble proteomes measured by rates of methionine oxidation

Sina Ghaemmaghami

Break

SESSION 5: NC INTERACTIONS

Chair: Susan Marqusee

Talk: Tracking protein co-translational folding with single mRNA resolution in living cells

Ning Zhao

Talk: AP Profiling resolves co-translational folding pathways and chaperone interactions in cells

Christian Kaiser

Focus Talk: Principle of cotranslational protein targeting to mitochondria

Shu-ou Shan

Lunch

SESSION 6: TRANSLATIONAL TUNING

Chair: Anton Komar

Talk: Vectorial appearance induces conformational biases that alter protein folding yield

Patricia Clark

Talk: Uncovering Model protein characteristics that are Codon and Codon-Pair optimized

Chava Kimchi-Sarfaty

Talk: Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding

Yi Liu

Break

Talk: Dwelling of ribosomes at rare arginine codons and production of chaperones connect the Puf3 pumilio family RNA binding protein and Not4 to protein homeostasis

Martine Collart

Short Talk: Short-circuiting the bacterial ribosome: RAPPing about hydrogens 1

Martino Morici

Short Talk: Short-circuiting the bacterial ribosome: RAPPing about hydrogens 2

Felix Gersteuer

Short Talk: Mechanisms of Translational Stalling and Recovery in Bacterial Ribosomes Studied by MD Simulations

Lars Bock

Talk: New functional insights into SRP-Mediated Protein Targeting to the Endoplasmic Reticulum

Guenter Kramer

Focus Talk: Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brain

Judith Frydman

Dinner

Poster Session 2

Wed, December 18

SESSION 7: TRANSLATIONAL TUNING

Chair: John Christodoulou

Talk: Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences

Olivia Rissland

Talk: The yeast E3 ligase Hel2 monitors the duration of ribosome stalling

Sabine Rospert

Talk: The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

David Balchin

Talk: How Amino Acid Chemistry at the Ribosome A- and P-sites Modulate Translation Elongation Speed

Ed O'Brien

Keynote Talk: Profiling analysis of co-translational folding and assembly of newly synthesized proteins

Bernd Bukau

Closing Remarks

Closing remarks and poster awards

Informal Discussions

Lunch